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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen mpi-cbg 2003     Display Documents



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ID: 15473.0, MPI für molekulare Zellbiologie und Genetik / Publikationen mpi-cbg 2003
Planar cell polarization requires Widerborst, a B ' regulatory subunit of protein phosphatase 2A
Authors:Hannus, M.; Feiguin, F.; Heisenberg, C. P.; Eaton, S.
Language:English
Date of Publication (YYYY-MM-DD):2002-07
Title of Journal:Development
Journal Abbrev.:Development
Volume:129
Issue / Number:14
Start Page:3493
End Page:3503
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a conserved component of planar cell polarization mechanisms in both Drosophila and in zebrafish. In Drosophila, wdb acts at two steps during planar polarization of wing epithelial cells. It is required to organize tissue polarity proteins into proximal and distal cortical domains, thus determining wing hair orientation. It is also needed to generate the polarized membrane outgrowth that becomes the wing hair. Widerborst activates the catalytic subunit of PP2A and localizes to the distal side of a planar microtubule web that lies at the level of apical cell junctions. This suggests that polarized PP2A activation along the planar microtubule web is important for planar polarization. In zebrafish, two wdb homologs are required for convergent extension during gastrulation, supporting the conjecture that Drosophila planar cell polarization and vertebrate gastrulation movements are regulated by similar mechanisms.
Free Keywords:Drosophila; Widerborst; PP2A; zebrafish; planar polarity
Comment of the Author/Creator:Date: 2002, JUL
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:ISI:000177325500019 [ID No:1]
ISSN:0950-1991 [ID No:2]
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