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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen mpi-cbg 2003     Display Documents



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ID: 15629.0, MPI für molekulare Zellbiologie und Genetik / Publikationen mpi-cbg 2003
On the importance of being co-transcriptional
Authors:Neugebauer, K. M.
Language:English
Date of Publication (YYYY-MM-DD):2002-10-15
Title of Journal:Journal of Cell Science
Journal Abbrev.:J. Cell Sci.
Volume:115
Issue / Number:20
Start Page:3865
End Page:3871
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Intense research in recent years has shown that many pre-mRNA processing events are co-transcriptional or at least begin during RNA synthesis by RNA polymerase II (Pol II). But is it important that pre-mRNA processing occurs co-transcriptionally? Whereas Pol II directs 5' capping of mRNA by binding to and recruiting all three capping activities to transcription units, co-transcriptional splicing is not obligatory. In some cases, such as alternative splicing, splicing may occur post- transcriptionally owing to the slower kinetics of splicing unfavorable introns. Despite recent models in which splicing factors are bound directly to the C-terminal domain (CTD) of Pol II, little evidence supports that view. Instead, interactions between snRNPs and transcription elongation factors provide the strongest molecular evidence for a physical link between transcription and splicing. Transcription termination depends on polyadenylation signals, but, like splicing, polyadenylation per se probably begins co- transcriptionally and continues post-transcriptionally. Nascent RNA plays an important role in determining which transcripts are polyadenylated and which alternative terminal exon is used. A recent addition to co-transcriptional RNA processing is a possible RNA surveillance step prior to release of the mRNP from the transcription unit, which appears to coordinate nuclear transport with mRNA processing and may be mediated by components of the nuclear exosome.
Free Keywords:RNA polymerase II; pre-mRNA processing; transcription unit; pre-mRNA splicing; polyadenylation; 5 ' end capping of mRNA; nuclear export
Comment of the Author/Creator:Date: 2002, OCT 15
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:ISI:000179179800002 [ID No:1]
ISSN:0021-9533 [ID No:2]
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