Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 2 (bis 2006) - Uli Schwarz     Display Documents



  history
ID: 16312.0, MPI für Entwicklungsbiologie / Abteilung 2 (bis 2006) - Uli Schwarz
The agrin/muscle-specific kinase pathway: New targets for autoimmune and genetic disorders at the neuromuscular junction
Authors:Liyanage, Y.; Hoch, W.; Beeson, D.; Vincent, A.
Language:English
Date of Publication (YYYY-MM-DD):2002-01
Title of Journal:Muscle & Nerve
Journal Abbrev.:Muscle Nerve
Volume:25
Issue / Number:1
Start Page:4
End Page:16
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The increasing understanding of the structural complexity of the neuromuscular junction (NMJ), and the processes that are important in its development, suggests many possible new disease targets. Here, we summarize briefly the genetic and autoimmune disorders that affect neuromuscular transmission, and the identified targets, including new evidence that antibodies to muscle-specific receptor tyrosine kinase (MuSK) are involved in the pathogenesis of acetylcholine receptor (AChR) antibody-negative myasthenia gravis. We then review the development of the NMJ, focusing on the important roles of nerve-derived agrin and MuSK in clustering of AChRs and other essential components of the NMJ. (C) 2002 John Wiley & Sons, Inc.
Free Keywords:agrin congenital myasthenic syndromes; muscle-specific kinase (MuSK); myasthenia gravis; seronegative myasthenia; neuromuscular junction; neuromuscular transmission
Comment of the Author/Creator:Date: 2002, JAN
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 2 - Biochemie (Uli Schwarz)
External Affiliations:John Radcliffe Hosp, Inst Mol Med, Neurosci Grp, Oxford OX3; 9DS, England
Identifiers:ISI:000172928500003 [ID No:1]
ISSN:0148-639X [ID No:2]
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.