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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 6 - Molecular Biology (D. Weigel)     Display Documents

ID: 16333.0, MPI für Entwicklungsbiologie / Abteilung 6 - Molecular Biology (D. Weigel)
The extent of linkage disequilibrium in Arabidopsis thaliana
Authors:Nordborg, M.; Borevitz, J. O.; Bergelson, J.; Berry, C. C.; Chory, J.; Hagenblad, J.; Kreitman, M.; Maloof, J. N.; Noyes, T.; Oefner, P. J.; Stahl, E. A.; Weigel, D.
Date of Publication (YYYY-MM-DD):2002-02
Title of Journal:Nature Genetics
Journal Abbrev.:Nature Genet.
Issue / Number:2
Start Page:190
End Page:193
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Linkage disequilibrium (LD), the nonrandom occurrence of alleles in haplotypes, has long been of interest to population geneticists. Recently, the rapidly increasing availability of genomic polymorphism data has fueled interest in LD as a tool for fine-scale mapping, in particular for human disease loci(1). The chromosomal extent of LD is crucial in this context, because it determines how dense a map must be for associations to be detected and, conversely, limits how finely loci may be mapped(2). Arabidopsis thaliana is expected to harbor unusually extensive LD because of its high degree of selfing(3). Several polymorphism studies have found very strong LD within individual loci, but also evidence of some recombination(4-6). Here we investigate the pattern of LD on a genomic scale and show that in global samples, LD decays within approximately 1 cM, or 250 kb. We also show that LD in local populations may be much stronger than that of global populations, presumably as a result of founder events. The combination of a relatively high level of polymorphism and extensive haplotype structure bodes well for developing a genome-wide LD map in A. thaliana.
Comment of the Author/Creator:Date: 2002, FEB
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 6 - Molekulare Biologie (Detlef Weigel)
External Affiliations:Univ So Calif, Dept Biol Sci, Los Angeles, CA 90089 USA; Salk Inst Biol Studies, Plant Biol Lab, La Jolla, CA 92037 USA; Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA; Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA; Howard Hughes Med Inst, La Jolla, CA USA; Lund Univ, Dept Genet, S-22362 Lund, Sweden; Stanford Univ, Dept Biochem, Sch Med, Stanford, CA 94305 USA
Identifiers:ISI:000173708700020 [ID No:1]
ISSN:1061-4036 [ID No:2]
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