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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents



  history
ID: 16367.0, MPI für Entwicklungsbiologie / Abteilungsunabhängige Arbeitsgruppen
RGM is a repulsive guidance molecule for retinal axons
Authors:Monnier, P. P.; Sierra, A.; Macchi, P.; Deitinghoff, L.; Andersen, J. S.; Mann, M.; Flad, M.; Hornberger, M. R.; Stahl, B.; Bonhoeffer, F.; Mueller, B. K.
Language:English
Date of Publication (YYYY-MM-DD):2002-09-26
Title of Journal:Nature
Journal Abbrev.:Nature
Volume:419
Issue / Number:6905
Start Page:392
End Page:395
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Axons rely on guidance cues to reach remote targets during nervous system development(1). A well-studied model system for axon guidance is the retinotectal projection. The retina can be divided into halves; the nasal half, next to the nose, and the temporal half. A subset of retinal axons, those from the temporal half, is guided by repulsive cues expressed in a graded fashion in the optic tectum(2,3), part of the midbrain. Here we report the cloning and functional characterization of a membrane-associated glycoprotein, which we call RGM (repulsive guidance molecule). This molecule shares no sequence homology with known guidance cues, and its messenger RNA is distributed in a gradient with increasing concentration from the anterior to posterior pole of the embryonic tectum. Recombinant RGM at low nanomolar concentration induces collapse of temporal but not of nasal growth cones and guides temporal retinal axons in vitro, demonstrating its repulsive and axon-specific guiding activity.
Comment of the Author/Creator:Date: 2002, SEP 26
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilungsunabhängige Arbeitsgruppen
External Affiliations:Migragen AG, Spemannstr 34, D-72076 Tubingen, Germany; Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense, Denmark; Develogen AG, D-37079 Gottingen, Germany
Identifiers:ISI:000178195400045 [ID No:1]
ISSN:0028-0836 [ID No:2]
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