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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents



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ID: 16403.0, MPI für Entwicklungsbiologie / Abteilungsunabhängige Arbeitsgruppen
beta-catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes
Authors:Posthaus, H.; Williamson, L.; Baumann, D.; Kemler, R.; Caldelari, R.; Suter, M. M.; Schwarz, H.; Muller, E.
Language:English
Date of Publication (YYYY-MM-DD):2002-12-01
Title of Journal:Journal of Cell Science
Journal Abbrev.:J. Cell Sci.
Volume:115
Issue / Number:23
Start Page:4587
End Page:4595
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Despite the pivotal role of beta-catenin in a variety of biological processes, conditional beta-catenin gene ablation in the skin of transgenic mice failed to affect interfollicular epidermal morphogenesis. We elucidated the molecular mechanisms underlying this phenomenon. Long-term cultures of homozygous, heterozygous and beta-catenin-null mutant keratinocytes were established to demonstrate that epidermal keratinocyte proliferation, cell cycle progression and cyclin D1 expression occur independently of beta-catenin and correlate with repression of transcription from Tcf/Lef-responsive promoters. Moreover, during differentiation, beta-catenin-null cells assemble normal intercellular adhesion junctions owing to the substitution of beta-catenin with plakoglobin, whereas the expression of the other adhesion components remains unaffected. Taken together, our results demonstrate that epidermal proliferation and adhesion are independent of beta-catenin.
Free Keywords:keratinocytes; epidermal renewal; plakoglobin; Wnt signaling
Comment of the Author/Creator:Date: 2002, DEC 1
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilungsunabhängige Arbeitsgruppen
External Affiliations:Univ Bern, Inst Anim Pathol, Langgassstr 122, CH-3012 Bern,; Switzerland; Max Planck Inst Immunobiol, D-7800 Freiburg Zahringen, Germany
Identifiers:ISI:000179845400018 [ID No:1]
ISSN:0021-9533 [ID No:2]
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