Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für biophysikalische Chemie     Collection: Molekulare Zellbiologie (Prof. Peter Gruss)     Display Documents



  history
ID: 16633.0, MPI für biophysikalische Chemie / Molekulare Zellbiologie (Prof. Peter Gruss)
Conversion of cerebral cortex into basal ganglia in Emx2-/- Pax6sey/sey double-mutant mice
Authors:Muzio, L.; DiBenedetto, B.; Stoykova, A.; Boncinelli, E.; Gruss, P.; Mallamaci, A.
Language:English
Date of Publication (YYYY-MM-DD):2002-08
Title of Journal:Nature Neuroscience
Volume:5
Issue / Number:8
Start Page:737
End Page:745
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual selector genes activating corticogenesis have not yet been identified. Here we show that high-level expression of at least one functional allele of either of the homeobox genes Emx2 or Pax6 in the dorsal telencephalon is necessary and sufficient to stably activate morphogenesis of cerebral cortex and to repress that of adjacent structures, such as striatum.
Comment of the Author/Creator:Date: 2002, AUG
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Peter Gruss / 160
MPI für biophysikalische Chemie/AG Anastassia Stoykova
External Affiliations:Ist Sci H San Raffaele, Dept Biol & Technol Res DIBIT, Via; Olgettina 58, I-20132 Milan, Italy; Scuola Int Super Studi Avanzati, I-34014 Trieste, Italy
Identifiers:URL:http://www.nature.com/neuro/journal/v5/n8/pdf/nn89...
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.