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          Institute: MPI für biophysikalische Chemie     Collection: Molekulare Entwicklungsbiologie (Prof. Herbert Jäckle)     Display Documents

ID: 16672.0, MPI für biophysikalische Chemie / Molekulare Entwicklungsbiologie (Prof. Herbert Jäckle)
Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway
Authors:Karsten, P.; Haeder, S.; Zeidler, M. P.
Date of Publication (YYYY-MM-DD):2002-09
Title of Journal:Mechanisms of Development
Issue / Number:1-2
Start Page:343
End Page:346
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The suppressor of cytokine signalling (SOCS) gene family was originally identified as an immediate early response to cytokine signalling and function as negative regulators of the Janus kinase (JAK)/signal tranducers and activators of transcription (STAT) signal transduction pathway [Krebs and Hilton, J. Cell Sci. 113 (2000) 2813; Starr and Hilton, Int. J. Biochem. Cell Biol. 30 (1998) 1081]. Although key components of the Drosophila JAK/STAT pathway have been identified [Brown et al., Curr. Biol. 11 (2001) 1700, reviewed in Zeidler et al., Oncogene 19 (2000) 2598], regulators of the pathway, and SOCS genes in particular, have not yet been characterised. Here we report the cloning of Drosophila SOCS36E and show its expression pattern during embryonic and imaginal disc development. SOCS36E is expressed in an essentially identical pattern to the Drosophila JAK/STAT pathway ligand unpaired (Upd). It is not expressed in upd mutant embryos and is upregulated in response to ectopic activation of the pathway during both embryonic and imaginal development. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Free Keywords:SOCS36E; suppressor of cytokine signalling; SOCS-5; CIS; janus kinase; signal tranducers and activators of transcription; STAT92E; unpaired; domeless; Drosophila melanogaster; marelle; hopscotch; SH2
Comment of the Author/Creator:Date: 2002, SEP
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Herbert Jäckle / 170
MPI für biophysikalische Chemie/AG Martin Zeidler
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