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          Institute: MPI für biophysikalische Chemie     Collection: Molekulare Zellbiologie (Prof. Peter Gruss)     Display Documents

ID: 16678.0, MPI für biophysikalische Chemie / Molekulare Zellbiologie (Prof. Peter Gruss)
Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle
Authors:Baeumer, N.; Marquardt, T.; Stoykova, A.; Ashery-Padan, R.; Chowdhury, K.; Gruss, P.
Date of Publication (YYYY-MM-DD):2002-10
Title of Journal:Development
Issue / Number:19
Start Page:4535
End Page:4545
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The establishment of polarity is an important step during organ development. We assign a function for the paired and homeodomain transcription factor Pax6 in axis formation in the retina. Pax6 is a key factor of the highly conserved genetic network implic ated in directing the initial phases of eye development. We recently demonstrated that Pax6 is also essential for later aspects of eye development, such as lens formation and retinogenesis. In this study, we present evidence that a highly conserved intron ic enhancer, alpha, in the Pax6 gene is essential for the establishment of a distal(high)- proximal(low) gradient of Pax6 activity in the retina. In the mature retina, the activity mediated by the alpha-enhancer defines a population of retinal ganglion ce lls that project to two sickle-shaped domains in the superior colliculus and lateral geniculate nucleus. Deletion of the alpha-enhancer in vivo revealed that retinal Pax6 expression is regulated in two complementary topographic domains. We found that P ax6 activity is required for the establishment, as well as the maintenance of dorsal and nasotemporal characteristics in the optic vesicle and, later, the optic cup.t
Free Keywords:Pax6; enhancer; retina; autoregulation; axon guidance; superior colliculus; axis formation; BF-1; BF-2; mousetû
Comment of the Author/Creator:Date: 2002, OCT&
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Peter Gruss / 160
MPI für biophysikalische Chemie/AG Anastassia Stoykova
MPI für biophysikalische Chemie/AG Kamal Chowdhury
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