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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents

ID: 168935.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Identification of downstream targets of the nodal signaling pathway.
Authors:Bennett, James; Joubin, Kathy; Cheng, Simon; Aanstad, Pia; Lehrach, Hans; Schier, Alexander F.
Date of Publication (YYYY-MM-DD):2003-07-15
Title of Journal:Developmental Biology
Journal Abbrev.:Dev. Biol.
Issue / Number:2
Start Page:527
End Page:527
Copyright:Copyright © 2004 Elsevier Inc. All rights reserved
Review Status:not specified
Audience:Experts Only
Abstract / Description:Nodal signaling is critical for a variety of processes during vertebrate development, including gastrulation and left—right patterning. Although many of the molecules that play a role in
the transduction of Nodal signals are known, the current list of genes known to be regulated by Nodal signals is incomplete. We identified putative Nodal regulated genes by differential RNA hybridization against a zebrafish cDNA library of about 14,000 cDNAs. Putative Nodal-regulated genes were also identified by screening zebrafish gene expression databases for genes expressed in the margin or shield of early gastrula-stage embryos. Putative Nodal-regulated genes were then screened by in situ hybridization against wild-type and maternal-zygotic one eyed pinhead embryos, which lack all Nodal signaling. This led to the identification of 57 unique Nodal-regulated genes. We are currently analyzing the function and regulation of these genes.
Comment of the Author/Creator:Date: 2003, JUL 15
SDB Meeting Abstracts
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:NYU, Sch Med, Skirball Inst, Dev Genet Program, New York, NY USA.; Max Planck Inst Mol Genet, Berlin, Germany.
Identifiers:ISI:000184373300343 [ID No:1]
ISSN:0012-1606 [ID No:2]
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