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          Institute: MPI für biophysikalische Chemie     Collection: Molekulare Zellbiologie (Prof. Peter Gruss)     Display Documents

ID: 17034.0, MPI für biophysikalische Chemie / Molekulare Zellbiologie (Prof. Peter Gruss)
Intra- and interspecific variation in primate gene expression patterns
Authors:Enard, W.; Khaitovich, P.; Klose, J.; Zoellner, S.; Heissig, F.; Giavalisco, P.; Nieselt-Struwe, K.; Muchmore, E.; Varki, A.; Ravid, R.; Doxiadis, G. M.; Bontrop, R. E.; Paeaebo, S.
Date of Publication (YYYY-MM-DD):2002-04-12
Title of Journal:Science
Issue / Number:5566
Start Page:340
End Page:343
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects. The underlying genetic basis of many of these differences may be altered gene expression. We have compared the transcriptome in blood leukocytes, liver, and brain of humans, chimpanzees, orangutans, and macaques using microarrays, as well as protein expression patterns of humans and chimpanzees using two-dimensional get electrophoresis. We also studied three mouse species that are approximately as related to each other as are humans, chimpanzees, and orangutans. We identified species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain.
Comment of the Author/Creator:Date: 2002, APR 12
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Peter Gruss / 160
MPI für evolutionäre Anthropologie
MPI für molekulare Genetik
External Affiliations:Max Planck Inst Evolutionary Anthropol, Inselstr 22, D-04103; Leipzig, Germany; Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany; Inst Humangenet Charite, D-13353 Berlin, Germany; Max Planck Inst Mol Genet, D-14195 Berlin, Germany; Univ Calif San Diego, La Jolla, CA 92093 USA; Vet Adm Med Ctr, La Jolla, CA 92093 USA; Netherlands Brain Bank, Amsterdam, Netherlands; Biomed Primate Res Ctr, Rijswijk, Netherlands
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