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          Institute: MPI für biophysikalische Chemie     Collection: Neurobiologie (Prof. Reinhard Jahn)     Display Documents



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ID: 17087.0, MPI für biophysikalische Chemie / Neurobiologie (Prof. Reinhard Jahn)
Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs
Authors:Antonin, W.; Fasshauer, D.; Becker, S.; Jahn, R.; Schneider, T. R.
Language:English
Date of Publication (YYYY-MM-DD):2002-02
Title of Journal:Nature Structural Biology
Volume:9
Issue / Number:2
Start Page:107
End Page:111
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:SNARE proteins are crucial for intracellular membrane fusion in all eukaryotes. These proteins assemble into tight complexes that connect membranes and may induce fusion. The crystal structure of the neuronal core complex is represented by an unusually long bundle of four alpha-helices connected by 16 layers of mostly hydrophobic amino acids. Here we report the 1.9 Angstrom resolution crystal structure of an endosomal SNARE core complex containing four SNAREs: syntaxin 7, syntaxin 8, vti1b and endobrevin/VAMP-8. Despite limited sequence homology, the helix alignment and the layer structure of the endosomal complex are remarkably similar to those of the neuronal complex. However, subtle variations are evident that characterize different SNARE subfamilies. We conclude that the structure of the SNARE core complex is an evolutionarily conserved hallmark of all SNARE complexes and is intimately associated with the general role of SNAREs in membrane fusion.
Comment of the Author/Creator:Date: 2002, FEB
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Reinhard Jahn / 190
MPI für biophysikalische Chemie/Abt. Christian Griesinger / 030
MPI für biophysikalische Chemie/AG Dirk Fasshauer
Identifiers:URL:http://www.nature.com/nsmb/journal/v9/n2/pdf/nsb74...
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