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          Institute: MPI für biophysikalische Chemie     Collection: Neurobiologie (Prof. Reinhard Jahn)     Display Documents

ID: 17114.0, MPI für biophysikalische Chemie / Neurobiologie (Prof. Reinhard Jahn)
Porocytosis: a new approach to synaptic function
Authors:Kriebel, M. E.; Keller, B.; Silver, R. B.; Fox, G. Q.; Pappas, G. D.
Date of Publication (YYYY-MM-DD):2001-12
Title of Journal:Brain Research Reviews
Issue / Number:1-2
Start Page:20
End Page:32
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:We propose a new approach to address the question of how a single quantum of neurotransmitter is secreted from a presynaptic terminal whose clustered secretory vesicles are locally bathed in high levels of calcium ions [Proceedings of the Symposium on Bioelectrogenesis (1961) 297-309; The Physiology of Synapses (1964) Chapters 1, 4, 5, 6; How the Self Controls its Brain (1994) Chapters 1, 4, 5, 6; Science 256 (1992) 677-679]. This hypothesis, which we term 'porocytosis', posits that the post-synaptic quantal response results from transmitter secreted through an array of docked vesicle/secretory pore complexes. The transient increase in calcium ions, which results from the voltage activated calcium channels, stimulates the array of secretory pores to simultaneously flicker open to pulse transmitter. Porocytosis is consistent with the quantal nature of presynaptic secretion and transmission, and with available biochemical, morphological and physiological evidence. It explains the frequency dependency of quantal size as a function of the secretion process. It permits a signature amount of transmitter release for different frequencies allowing a given synapse to be employed in different behavioral responses. The porocytosis hypothesis pen-nits fidelity of secretion and the seemingly apposed characteristic of synaptic plasticity. The dynamics inherent in an array insure a constant quantal size as a function of the number of units within the array. In this hypothesis, plasticity is a consequence of concurrent pre- and post-synaptic changes due to a change in array size. Changes in the number of docked vesicle-secretory pore complexes composing the array can explain facilitation, depletion, graded excitation-secretion and long term plasticity. (C) 2001 Elsevier Science B.V. All rights reserved.
Free Keywords:transmitter secretion; quanta; porocytosis; porosome; synaptomere; synaptic vesicle
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/Abt. Reinhard Jahn / 190
External Affiliations:SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY; 13210 USA; SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA; Marine Biol Lab, Woods Hole, MA 02543 USA; Argonne Natl Lab, Decis & Informat Sci Div, Argonne, IL 60439 USA; Univ Illinois, Coll Med, Inst Psychiat, Chicago, IL 60612 USA
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