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          Institute: MPI für biophysikalische Chemie     Collection: Biomedizinische NMR ForschungsGmbH (Prof. Jens Frahm)     Display Documents



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ID: 17298.0, MPI für biophysikalische Chemie / Biomedizinische NMR ForschungsGmbH (Prof. Jens Frahm)
Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy
Authors:Brockmann, K.; Pouwels, P. J. W.; Dechent, P.; Flanigan, K. M.; Frahm, J.; Hanefeld, F.
Language:English
Date of Publication (YYYY-MM-DD):2003-01
Title of Journal:Brain & Development
Volume:25
Issue / Number:1
Start Page:45
End Page:50
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter. (C) 2002 Elsevier Science B.V. All rights reserved.
Free Keywords:magnetic resonance spectroscopy; giant axonal neuropathy; demyelination; leukoencephalopathy
Comment of the Author/Creator:Date: 2003, JAN
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/AG Jens Frahm
External Affiliations:Univ Gottingen, Childrens Hosp, Dept Pediat & Neuropediat,; Robert Koch Str 40, D-37075 Gottingen, Germany; Univ Gottingen, Childrens Hosp, Dept Pediat & Neuropediat, D-37075 Gottingen, Germany; Univ Utah, Sch Med, Dept Neurol, Salt Lake City, UT USA; Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA; Univ Utah, Sch Med, Dept Human Genet, Salt Lake City, UT 84132 USA
Identifiers:URL:http://www.sciencedirect.com/science?_ob=MImg&_ima...
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