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          Institute: MPI für experimentelle Medizin     Collection: Molecular Neurobiology     Display Documents

ID: 17314.0, MPI für experimentelle Medizin / Molecular Neurobiology
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs
Authors:Rhee, J. S.; Betz, Andrea; Pyott, S.; Reim, Kerstin; Varoqueaux, Frédérique; Augustin, I.; Hesse, D.; Südhof, Thomas C.; Takahashi, M.; Rosenmund, Christian; Brose, Nils
Date of Publication (YYYY-MM-DD):2002-01-11
Title of Journal:Cell
Journal Abbrev.:Cell
Issue / Number:1
Start Page:121
End Page:133
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Munc13-1 is a presynaptic protein with an essential role in synaptic vesicle priming. It contains a diacylglycerol (DAG)/beta phorbol ester binding C-1 domain and is a potential target of the DAG second messenger pathway that may act in parallel with PKCs. Using genetically modified mice that express a DAG/beta phorbol ester binding-deficient Munc13- 1(H567K) variant instead of the wild-type protein, we determined the relative contribution of PKCs and Munc13-1 to DAG/beta phorbol ester-dependent regulation of neurotransmitter release. We show that Munc13s are the main presynaptic DAG/beta phorbol ester receptors in hippocampal neurons. Modulation of Munc13-1 activity by second messengers via the DAG/beta phorbol ester binding C-1 domain is essential for use-dependent alterations of synaptic efficacy and survival.
External Publication Status:published
Document Type:Article
Communicated by:Nils Brose
Affiliations:MPI für experimentelle Medizin/Molecular neurobiology
External Affiliations:Max Planck Inst Biophys Chem, Abt Membranbiophys, Fassberg 11,; D-37077 Gottingen, Germany; Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Ctr Basic Neurosci,Dept Mol Genet, Dallas, TX 75390 USA; Mitsubishi Kasei Inst Life Sci, Tokyo 1948511, Japan
Identifiers:ISI:000173280700013 [ID No:1]
ISSN:0092-8674 [ID No:2]
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