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          Institute: MPI für molekulare Genetik     Collection: Department of Computational Molecular Biology     Display Documents

ID: 174824.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
Increase of functional diversity by alternative splicing
Authors:Kriventseva, Evgenia V.; Koch, Ina; Apweiler, Rolf; Vingron, Martin; Bork, Peer; Gelfand, Mikhail S.; Sunyaev, Shamil
Date of Publication (YYYY-MM-DD):2003-03
Title of Journal:Trends in Genetics
Journal Abbrev.:Trends Genet.
Issue / Number:3
Start Page:124
End Page:128
Copyright:Copyright © 2003 Elsevier Science Ltd. All rights reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:A large-scale analysis of protein isoforms arising from alternative splicing shows that alternative splicing tends to insert or delete complete protein domains more frequently than expected by chance, whereas disruption of domains and other structural modules is less frequent. If domain regions are disrupted, the functional effect, as predicted from 3D structure, is frequently equivalent to removal of the entire domain. Also, short alternative splicing events within domains, which might preserve folded structure, target functional residues more frequently than expected. Thus, it seems that positive selection has had a major role in the evolution of alternative splicing.
Comment of the Author/Creator:Available online 6 February 2003
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
External Affiliations:EBI, EMBL, Cambridge CB10 1SD, England.; Max Planck Inst Mol Genet, D-14195 Berlin, Germany.; Max Delbrueck Ctr Mol Med, D-13122 Berlin, Germany.; State Sci Ctr GosNllGenet, Moscow 113545, Russia.; European Mol Biol Lab, D-69117 Heidelberg, Germany.
Identifiers:ISI:000181584500004 [ID No:1]
ISSN:0168-9525 [ID No:2]
DOI:10.1016/S0168-9525(03)00023-4 [ID No:3]
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