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          Institute: MPI für molekulare Genetik     Collection: Department of Computational Molecular Biology     Display Documents



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ID: 175339.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
CORG: a database for COmparative Regulatory Genomics
Authors:Dieterich, Christoph; Wang, H.; Rateitschak, K.; Luz, Hannes; Vingron, Martin
Language:English
Date of Publication (YYYY-MM-DD):2003-01-01
Title of Journal:Nucleic Acids Research
Journal Abbrev.:Nucleic Acids Res.
Volume:31
Issue / Number:1
Start Page:55
End Page:57
Copyright:© 2003 Oxford University Press
Review Status:not specified
Audience:Experts Only
Abstract / Description:Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG—‘COmparative Regulatory Genomics’—database. The data were computed based on statistically significant local suboptimal alignments of 15 kb regions upstream of the translation start sites of, currently, 10 793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service (http://corg.molgen.mpg.de) for query and interactive visualization of the conserved blocks and their annotation.
Comment of the Author/Creator:Date: 2003, JAN 1
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
External Affiliations:Max Planck Inst Mol Genet, D-14195 Berlin, Germany.
Identifiers:ISI:000181079700010 [ID No:1]
ISSN:0305-1048 [ID No:2]
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