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          Institute: MPI für molekulare Genetik     Collection: Department of Computational Molecular Biology     Display Documents



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ID: 175672.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
Effect of routine repeat transurethral resection for superficial bladder cancer: A long-term observational study
Authors:Grimm, Marc-Oliver; Steinhoff, Christine; Simon, Xenia; Spiegelhalder, Philipp; Ackermann, Rolf; Vogeli, Thomas Alexander
Language:English
Date of Publication (YYYY-MM-DD):2003-08
Title of Journal:Journal of Urology
Journal Abbrev.:J. Urol.
Volume:170
Issue / Number:2
Start Page:433
End Page:437
Copyright:© 2003, American Urological Association
Review Status:not specified
Audience:Experts Only
Abstract / Description:Purpose: We determined the long-term outcome in patients with superficial bladder cancer (Ta and T1) undergoing routine second transurethral bladder tumor resection (ReTURB) in regard to recurrence and progression.

Materials and Methods: We performed an inception cohort study of 124 consecutive patients with superficial bladder cancer undergoing transurethral resection and routine ReTURB (83) between November 1993 and October 1995 at a German university hospital. Immediately after transurethral resection all lesions were documented on a designed bladder map. ReTURB of the scar from initial resection and other suspicious lesions was performed at a mean of 7 weeks. Patients were followed until recurrence or death, or a minimum of 5 years.

Results: Residual tumor was found in 33% of all ReTURB cases, including 27% of Ta and 53% of T1 disease, and in 81% at the initial resection site. Five of the 83 patients underwent radical cystectomy due to ReTURB findings. The estimated risk of recurrence after years 1 to 3 was 18%, 29% and 32%, respectively. After 5 years 63% of the patients undergoing ReTURB were still disease-free (mean recurrence-free survival 62 months, median 87). Progression to muscle invasive disease was observed in only 2 patients (3%) after a mean observation of 61 months.

Conclusions: These data suggest a favorable outcome regarding recurrence and progression in patients with superficial bladder cancer who undergo ReTURB. ReTURB is suggested at least in those at high risk when bladder preservation is intended.
Free Keywords:bladder; bladder neoplasms; urethra; transurethral resection; outcome; recurrence; progression
Comment of the Author/Creator:Date: 2003, Aug
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
External Affiliations:Univ Dusseldorf, Dept Urol, D-40225 Dusseldorf, Germany.; Max Planck Inst Mol Genet, Dept Computat Mol Biol, Berlin, Germany
Identifiers:ISI:000184134100020 [ID No:1]
ISSN:0022-5347 [ID No:2]
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