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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents



ID: 176168.0, MPI für Entwicklungsbiologie / Abteilungsunabhängige Arbeitsgruppen
A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication
Authors:Paukert, M.; Sidi, S.; Russell, C.; Siba, M.; Wilson, Stephen; Nicolson, Theresa; Grunder, S.
Language:English
Date of Publication (YYYY-MM-DD):2004-04
Title of Journal:J Biol Chem
Volume:279
Issue / Number:18
Start Page:18783
End Page:18791
Sequence Number of Article:14970195
Review Status:not specified
Audience:Not Specified
Abstract / Description:Acid-sensing ion channels (ASICs) are excitatory receptors for extracellular H(+). Proposed functions include synaptic transmission, peripheral perception of pain, and mechanosensation. Despite the physiological importance of these functions, the precise role of ASICs has not yet been established. In order to increase our understanding of the physiological role and basic structure-function relationships of ASICs, we report here the cloning of six new ASICs from the zebrafish (zASICs). zASICs possess the basic functional properties of mammalian ASICs: activation by extracellular H(+), Na(+) selectivity, and block by micromolar concentrations of amiloride. The zasic genes are broadly expressed in the central nervous system, whereas expression in the peripheral nervous system is scarce. This pattern suggests a predominant role for zASICs in neuronal communication. Our results suggest a conserved function for receptors of extracellular H(+) in the central nervous system of vertebrates.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilungsunabhängige Arbeitsgruppen
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