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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents



ID: 176172.0, MPI für Entwicklungsbiologie / Abteilungsunabhängige Arbeitsgruppen
Control of crystal size and lattice formation by starmaker in otolith biomineralization
Authors:Söllner, Christian; Burghammer, M.; Busch-Nentwich, Elisabeth; Berger, Juergen; Schwarz, Heinz; Riekel, C.; Nicolson, Theresa
Language:English
Date of Publication (YYYY-MM-DD):2003-10
Title of Journal:Science
Volume:302
Issue / Number:5643
Start Page:282
End Page:286
Sequence Number of Article:14551434
Review Status:not specified
Audience:Not Specified
Abstract / Description:The stone-like otoliths from the ears of teleost fishes are involved in balance and hearing and consist of calcium carbonate crystallites embedded in a protein framework. We report that a previously unknown gene, starmaker, is required in zebrafish for otolith morphogenesis. Reduction of starmaker activity by injection of modified antisense oligonucleotides causes a change in the crystal lattice structure and thus a change in otolith morphology. The expression pattern of starmaker, along with the presence of the protein on the growing otolith, suggest that the expression levels of starmaker control the shape of the otoliths.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilungsunabhängige Arbeitsgruppen
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