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          Institute: MPI für molekulare Genetik     Collection: Research Group Development and Disease     Display Documents



  history
ID: 178596.0, MPI für molekulare Genetik / Research Group Development and Disease
A single amphioxus and sea urchin runt-gene suggests that runt-gene duplications occurred in early chordate evolution
Authors:Stricker, S.; Poustka, A. J.; Wiecha, U.; Stiege, A.; Hecht, J.; Panopoulou, G.; Vilcinskas, A.; Mundlos, S.; Seitz, V.
Language:English
Date of Publication (YYYY-MM-DD):2003-09
Title of Journal:Developmental and Comparative Immunology
Journal Abbrev.:Dev. Comp. Immunol.
Volume:27
Issue / Number:8
Start Page:673
End Page:684
Copyright:© 2003 Elsevier Science Ltd
Review Status:not specified
Audience:Experts Only
Abstract / Description:Runt-homologous molecules are characterized by their DNA binding runt-domain which is highly conserved within bilaterians. The three mammalian runt-genes are master regulators in cartilage/bone formation and hematopoiesis. Historically these features evolved in Craniota and might have been promoted by runt-gene duplication events. The purpose of this study was therefore to investigate how many runt-genes exist in the stem species of chordates, by analyzing the number of runt-genes in what is likely to be the closest living relative of Craniota—amphioxus. To acquire further insight into the possible role of runt-genes in early chordate evolution we have determined the number of runt-genes in sea urchins and have analyzed the runt-expression pattern in this species.

Our findings demonstrate the presence of a single runt-gene in amphioxus and sea urchin, which makes it highly likely that the stem species of chordates harbored only a single runt-gene. This suggests that runt-gene duplications occurred later in chordate phylogeny, and are possibly also associated with the evolution of features such as hematopoiesis, cartilage and bone development.

In sea urchin embryos runt-expression involves cells of endodermal, mesodermal and ectodermal origin. This complex pattern of expression might reflect the multiple roles played by runt-genes in mammals. A strong runt-signal in the gastrointestinal tract of the sea urchin is in line with runt-expression in the intestine of nematodes and in the murine gastrointestinal tract, and seems to be one of the phylogenetically ancient runt-expression domains.
Free Keywords:runt; amphioxus; sea urchin; cartilage; bone; hematopoiesis; gene duplication; chordates
Comment of the Author/Creator:Date: 2003, Sep
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Stefan Mundlos
Affiliations:MPI für molekulare Genetik
External Affiliations:Max Planck Inst Mol Genet, D-14195 Berlin, Germany
Univ Potsdam, Syst Zool & Evolutionary Biol, D-14417 Potsdam, Germany
Identifiers:ISI:000183906600003 [ID No:1]
ISSN:0145-305X [ID No:2]
DOI:10.1016/S0145-305X(03)00037-5 [ID No:3]
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