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          Institute: MPI für experimentelle Medizin     Collection: Clinical Neuroscience     Display Documents



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ID: 18545.0, MPI für experimentelle Medizin / Clinical Neuroscience
Endothelin B receptor deficiency augments neuronal damage upon exposure to hypoxia-ischemia in vivo
Authors:Sirén, Anna Leena; Lewczuk, P.; Hasselblatt, M.; Dembowski, C.; Schilling, L.; Ehrenreich, Hannelore
Language:English
Date of Publication (YYYY-MM-DD):2002-07-26
Title of Journal:Brain Research
Journal Abbrev.:Brain Res.
Volume:945
Issue / Number:1
Start Page:144
End Page:149
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:The role of functional endothelin-B (ETB)-receptors on neuronal survival upon hypoxia-ischemia (HI) has been investigated in 14-day-old ETB-receptor-deficient spotting lethal (sl/sl) and wildtype (+/+) rats. Carotid ligation followed by exposure to 8% oxygen for 2 h produced distinct cortical and hippocampal neuronal damage. Damage severity 24 h after HI was mild to intermediate in +/+ rats whereas large cortical infarcts and profound apoptosis of the hippocampus evolved in sl/sl rats. The number of apoptotic cells in the dentate 24 h after HI amounted to 30+/-7 cells/0.1 mm(2) in sl/sl compared to 9+/- 3cells/0.1 mm(2) in wildtype rats (mean+/-S.E.M., n=10-11, P=0.0093). In-vitro hypoxia (15 h) resulted in a comparable increase in cell death in primary pure neuronal hippocampal cultures from both groups (49.8+/-1.6% in sl/sl, 51.4+/-0.9% in +/+, mean+/-S.E.M., n=5, P=0.0560). To conclude, absence of functional ETB receptors is associated with an increased susceptibility to HI in-vivo, which is not intrinsic to neurons. Antagonism of ETB receptors seems not to be desirable in ischemic stroke. (C) 2002 Elsevier Science B.V. All rights reserved.
Free Keywords:neurons; hypoxia; ischemia; spotting lethal; rat
Comment of the Author/Creator:Date: 2002, JUL 26
External Publication Status:published
Document Type:Article
Communicated by:Hannelore Ehrenreich
Affiliations:MPI für experimentelle Medizin/Clinical neuroscience
External Affiliations:Univ Gottingen, Dept Neurol & Psychiat, Hermann Rein Str 3, D-; 37075 Gottingen, Germany; Univ Hosp, Dept Neurosurg, Mannheim, Germany
Identifiers:ISI:000177224300019 [ID No:1]
ISSN:0006-8993 [ID No:2]
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