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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents



ID: 191164.0, MPI für Entwicklungsbiologie / Abteilungsunabhängige Arbeitsgruppen
NompC TRP channel required for vertebrate sensory hair cell mechanotransduction.
Authors:Sidi, Samuel; Friedrich, R. W.; Nicolson, Theresa
Language:English
Date of Publication (YYYY-MM-DD):2003-07
Title of Journal:Science
Volume:301
Issue / Number:5629
Start Page:96
End Page:99
Sequence Number of Article:12805553
Review Status:not specified
Audience:Not Specified
Abstract / Description:The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilungsunabhängige Arbeitsgruppen
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