Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Genetik     Collection: Research Group Development and Disease     Display Documents



  history
ID: 192424.0, MPI für molekulare Genetik / Research Group Development and Disease
Evolution of classic Hodgkin lymphoma in correlation to changes in the lymphoid organ structure of vertebrates
Authors:Seitz, Volker; Hummel, M.; Walter, J.; Stein, H.
Language:English
Date of Publication (YYYY-MM-DD):2003-01
Title of Journal:Developmental and Comparative Immunology
Journal Abbrev.:Dev. Comp. Immunol.
Volume:27
Issue / Number:1
Start Page:43
End Page:53
Copyright:© 2002 Elsevier Science Ltd. All rights reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:In order to integrate evolutionary concepts into lymphoma research we mapped features of classic Hodgkin lymphoma (a disease which has been recently described to be derived from germinal center B-cells) onto a phylogenetic tree of vertebrates. Secondly, we matched the phylogenetic occurrence of classic Hodgkin lymphoma to the changes in the lymphoid organ structure during vertebrate evolution. According to our analysis, classic Hodgkin lymphoma evolved exclusively at the developmental stage of mammals. Interestingly the appearance of Hodgkin lymphoma is correlated to the evolution of germinal centers in mammals. This lends some credit to the hypothesis that genes specific to the germinal center reaction are involved in the pathogenesis of Hodgkin lymphoma. However, as evolution did not stop at the developmental stage of the mammalian stem-species, to a certain extent species with specific differences of classic Hodgkin lymphoma can be expected. One such difference is that classic Hodgkin lymphoma occurs with a significantly higher frequency in humans than in all other mammals. This could be partially due to Epstein–Barr virus (EBV) infection in approximately 40%–50% of Hodgkin disease cases, that is associated with an expression of the EBV-encoded oncogen LMP-1. In conclusion we propose that the mapping of lymphoma related characteristics onto a phylogenetic tree is a valuable new tool in lymphoma research.
Free Keywords:B-cell lymphoma, classic Hodgkin lymphoma, evolution, phylogeny, ontogeny, Epstein-Barr virus, germinal center, pathology
Comment of the Author/Creator:Date: 2003, JAN
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Stefan Mundlos
Affiliations:MPI für molekulare Genetik
External Affiliations:Max Planck Inst Mol Genet, D-14195 Berlin, Germany.; Free Univ Berlin, Inst Pathol, D-12200 Berlin, Germany.; BASF AG, D-67056 Ludwigshafen, Germany.
Identifiers:ISI:000180076900006 [ID No:1]
ISSN:0145-305X [ID No:2]
DOI:10.1016/S0145-305X(02)00042-3 [ID No:3]
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.