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          Institute: MPI für Festkörperforschung     Collection: FKF Publikationen 2004     Display Documents



  history
ID: 192700.0, MPI für Festkörperforschung / FKF Publikationen 2004
Binding the tobacco mosaic virus to inorganic surfaces
Authors:Knez, M.; Sumser, M. P.; Bittner, A. M.; Wege, C.; Jeske, H.; Hoffmann, D. M. P.; Kuhnke, K.; Kern, K.
Language:English
Date of Publication (YYYY-MM-DD):2004
Title of Journal:Langmuir
Volume:20
Issue / Number:2
Start Page:441
End Page:447
Review Status:not specified
Audience:Not Specified
Abstract / Description:We studied the adsorption behavior and surface chemistry of the tobacco
mosaic virus (TMV) on well-defined metal and insulator surfaces. TMV
serves as a tubular supramolecular model system with precisely known
surface termination. We show that if the surface chemistry of the
substrate and the pH-dependent chemistry of the molecular surface
match, for example, by hydrogen bonding, a strong adsorption occurs,
and lateral movement is impeded. Due to the immobilization, the virion
can be imaged by atomic force microscopy (AFM) in contact mode. We also
used self-assembled monolayers with an acyl chloride group to induce
covalent bonding via ester formation. Noncontact AFM proved that TMV
keeps its cylindrical cross section only under weak adsorption
conditions, that is, on hydrophobic surfaces, while on hydrophilic
substrates a deformation occurs to maximize the number of interacting
chemical groups.
External Publication Status:published
Document Type:Article
Communicated by:Michaela Asen-Palmer
Affiliations:MPI für Festkörperforschung
External Affiliations:Max Planck Inst Festkorperforsch, D-70569 Stuttgart, Germany.
; Univ Stuttgart, Inst Biol, D-70550 Stuttgart, Germany.
Identifiers:ISI:000188220600026 [ID No:1]
ISSN:0743-7463 [ID No:2]
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