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          Institute: MPI für molekulare Genetik     Collection: Department of Human Molecular Genetics     Display Documents



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ID: 194742.0, MPI für molekulare Genetik / Department of Human Molecular Genetics
DNA methylation in placentas of interspecies mouse hybrids
Authors:Schutt, Sabine; Florl, Andrea R.; Shi, Wei; Hemberger, Myriam; Orth, Anni; Otto, Sabine; Schulz, Wolfgang A.; Fundele, Reinald H.
Language:English
Date of Publication (YYYY-MM-DD):2003-09
Title of Journal:Genetics
Journal Abbrev.:Genetics
Volume:165
Issue / Number:1
Start Page:223
End Page:228
Copyright:Copyright © 2003
Review Status:not specified
Audience:Experts Only
Abstract / Description:Interspecific hybridization in the genus Mus results in several hybrid dysgenesis effects, such as male sterility and X-linked placental dysplasia (IHPD). The genetic or molecular basis for the placental phenotypes is at present not clear. However, an extremely complex genetic system that has been hypothesized to be caused by major epigenetic changes on the X chromosome has been shown to be active. We have investigated DNA methylation of several single genes, Atrx, Esx1, Mecp2, Pem, Psx1, Vbp1, Pou3f4, and Cdx2, and, in addition, of LINE-1 and IAP repeat sequences, in placentas and tissues of fetal day 18 mouse interspecific hybrids. Our results show some tendency toward hypomethylation in the late gestation mouse placenta. However, no differential methylation was observed in hyper- and hypoplastic hybrid placentas when compared with normal-sized littermate placentas or intraspecific Mus musculus placentas of the same developmental stage. Thus, our results strongly suggest that generalized changes in methylation patterns do not occur in trophoblast cells of such hybrids.
Comment of the Author/Creator:Date: 2003, SEP
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Hans-Hilger Ropers
Affiliations:MPI für molekulare Genetik
External Affiliations:Uppsala Univ, Dept Genet & Dev, S-75236 Uppsala, Sweden.; Max Planck Inst Mol Genet, D-14195 Berlin, Germany.; Univ Dusseldorf, Dept Oncol, D-40225 Dusseldorf, Germany.; Univ Montpellier 2, Lab Genome & Populat, F-34095 Montpellier 5, France.
Identifiers:ISI:000185618200017 [ID No:1]
ISSN:0016-6731 [ID No:2]
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