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          Institute: Rechenzentrum Garching     Collection: Rechenzentrum Garching     Display Documents

ID: 198258.0, Rechenzentrum Garching / Rechenzentrum Garching
Complete genome sequence and analysis of Wolinella succinogenes
Authors:Baar, C.; Eppinger, M.; Raddatz, G.; Simon, J.; Lanz, C.; Klimmek, O.; Nandakumar, R.; Gross, R.; Rosinus, A.; Keller, H.; Jagtap, P.; Linke, B.; Meyer, F.; Lederer, H.; Schuster, S. C.
Date of Publication (YYYY-MM-DD):2003
Title of Journal:Proceedings of the National Academy of Sciences of the United States of America
Issue / Number:20
Start Page:11690
End Page:11695
Copyright:Copyright © 2003 by the National Academy of Sciences
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:To understand the origin and emergence of pathogenic bacteria, knowledge of the genetic inventory from their nonpathogenic relatives is a prerequisite. Therefore, the 2.11-megabase genome sequence of Wolinella succinogenes, which is closely related to the pathogenic bacteria Helicobacter pylori and Campylobacter jejuni, was determined. Despite being considered nonpathogenic to its bovine host, W. succinogenes holds an extensive repertoire of genes homologous to known bacterial virulence factors. Many of these genes have been acquired by lateral gene transfer, because part of the virulence plasmid pVir and an N-linked glycosylation gene cluster were found to be syntenic between C. jejuni and genomic islands of W. succinogenes. In contrast to other host-adapted bacteria, W. succinogenes does harbor the highest density of bacterial sensor kinases found in any bacterial genome to date, together with an elaborate signaling circuitry of the GGDEF family of proteins. Because the analysis of the W. succinogenes genome also revealed genes related to soil- and plant-associated bacteria such as the nif genes, W. succinogenes may represent a member of the epsilon proteobacteria with a life cycle outside its host.
Free Keywords:Helicobacter, Campylobacter, epsilon proteobacteria, bacterial pathogenicity
External Publication Status:published
Document Type:Article
Affiliations:Rechenzentrum Garching
MPI für Entwicklungsbiologie
MPI für Plasmaphysik/RZG
External Affiliations:Institute of Microbiology, Johann Wolfgang Goethe University, 60439 Frankfurt am Main, Germany; Center for Biotechnology, Bielefeld University, 33594 Bielefeld, Germany
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