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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Publikationen des W. G. Kerckhoff-Instituts     Display Documents

ID: 199046.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Publikationen des W. G. Kerckhoff-Instituts
Remodeling of the adventitia during coronary arteriogenesis
Authors:Cai, W. J.; Koltai, S.; Kocsis, E.; Scholz, D.; Kostin, S.; Luo, X.; Schaper, W.; Schaper, J.
Date of Publication (YYYY-MM-DD):2003-01
Title of Journal:Am J Physiol Heart Circ Physiol
Issue / Number:1
Start Page:H31
End Page:40
Review Status:not specified
Audience:Not Specified
Abstract / Description:We studied the role of the adventitia in adaptive arteriogenesis during the phase of active growth of coronary collateral vessels (CV) induced by chronic occlusion of the left circumflex coronary artery in canine hearts. We used electron microscopy and immunoconfocal (IF) labeling for bFGF, matrix metalloproteinase (MMP)-2, MMP-9, tissue-type plasminogen activator (tPA), its inhibitor (PAI-1), fibronectin (FN), and Ki-67. Proliferation of smooth muscle cells and adventitial fibroblasts was evident. Quantitative IF showed that adventitial MMP-2, MMP-9, and FN were 9.2-, 7.5-, and 8.6-fold, bFGF was 5.1-fold, and PAI-1 was 3.4-fold higher in CV than in normal vessels (NV). The number of fibroblasts was 5-fold elevated in CV, but the elastic fiber content was 25-fold greater in NV than in CV. Perivascular myocyte damage and induction of endothelial nitric oxide synthase in peri-CV capillaries indicate expansion of CV. It was concluded that adventitial activation is associated with the development of CV through cell proliferation, production of growth factors, and induction of extracellular proteolysis thereby contributing to remodeling during adaptive arteriogenesis.
Free Keywords:Animals
; Arteries/physiopathology
; Blood Vessels/physiopathology
; Cell Division
; Collateral Circulation
; Connective Tissue/pathology/*physiopathology
; Coronary Disease/pathology/*physiopathology
; Coronary Vessels/*physiopathology
; Dogs
; Fibroblast Growth Factor 2/metabolism
; Fibroblasts/physiology
; Fibronectins/metabolism
; Gelatinase A/metabolism
; Gelatinase B/metabolism
; Growth
; Ki-67 Antigen/metabolism
; Metalloendopeptidases/metabolism
; Neovascularization, Physiologic/*physiology
; Phenotype
; Plasminogen Activator Inhibitor 1/metabolism
; Reference Values
; Tissue Plasminogen Activator/metabolism
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für physiologische und klinische Forschung
Identifiers:URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... [ID No:1]
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