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          Institute: MPI für biophysikalische Chemie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents

ID: 20759.0, MPI für biophysikalische Chemie / Abteilungsunabhängige Arbeitsgruppen
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon
Authors:Altrock, W. D.; Dieck, S. T.; Sokolov, M.; Meyer, A. C.; Sigler, A.; Brakebusch, C.; Fassler, R.; Richter, K.; Boeckers, T. M.; Potschka, H.; Brandt, C.; Loscher, W.; Grimberg, D.; Dresbach, T.; Hempelmann, A.; Hassan, H.; Balschun, D.; Frey, J. U.; Brandstaetter, J. H.; Garner, C. C.; Rosenmund, C.; Gundelfinger, E. D.
Date of Publication (YYYY-MM-DD):2003-03-06
Title of Journal:Neuron
Issue / Number:5
Start Page:787
End Page:800
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are unable to fuse. Phenotypically, the loss of Bassoon causes spontaneous epileptic seizures. These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses.
Comment of the Author/Creator:Date: 2003, MAR 6
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für biophysikalische Chemie/AG Christian Rosenmund
MPI für biophysikalische Chemie/Abt. Erwin Neher / 140
External Affiliations:Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany; Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany; Max Planck Inst Brain Res, Dept Neuroanat, D-60528 Frankfurt, Germany; Max Planck Inst Biochem, Dept Mol Med, D-82152 Martinsried, Germany; Otto Von Guericke Univ, Inst Med Neurobiol, D-39120 Magdeburg, Germany; Univ Munster, Inst Anat, D-48149 Munster, Germany; Hannover Sch Vet Med, Dept Pharmacol Toxicol & Pharm, D-30559 Hannover, Germany; Stanford Univ, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA
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