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          Institute: MPI für experimentelle Endokrinologie     Collection: Abteilung Eichele     Display Documents



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ID: 214426.0, MPI für experimentelle Endokrinologie / Abteilung Eichele
Differential expression of atypical PKCs in the adult mouse brain
Authors:Oster, H.; Eichele, G.; Leitges, M.
Language:English
Date of Publication (YYYY-MM-DD):2004-08-23
Title of Journal:Brain Res Mol Brain Res
Volume:127
Issue / Number:1-2
Start Page:79
End Page:88
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:The protein kinase C (PKC) family of serine/threonine kinases plays a role in a variety of physiological and pathophysiological processes in the brain including development, synaptic plasticity, epilepsy, ischemia, and neuronal cell death. The subgroup of atypical PKCs (aPKCs) comprises of three members, PKCiota/lambda, PKCzeta, and PKMzeta, with high amino acid homology. We used specific RNA probes and in situ hybridization to determine the expression patterns of all the three isoforms in the adult mouse brain. PKCiota and PKMzeta were found to be broadly expressed in most of the cortex, the limbic system, and the thalamus. In contrast, PKCzeta transcription was restricted to distinct forebrain areas and the cerebellum. Here we present a first comprehensive overview of isotype-specific aPKC distribution in the central nervous system, thereby providing a solid ground for further studies on the functional implications of the different aPKCs in the neuronal system.
Free Keywords:Animals
; Brain/anatomy & histology/*enzymology/metabolism
; Comparative Study
; In Situ Hybridization/methods
; Isoenzymes/*metabolism
; Male
; Mice
; Mice, Inbred C57BL
; Molecular Sequence Data
; Protein Kinase C/classification/genetics/*metabolism
External Publication Status:published
Document Type:Article
Affiliations:MPI für experimentelle Endokrinologie
Identifiers:URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... [ID No:1]
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