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          Institute: MPI für evolutionäre Anthropologie     Collection: Publications MPI for Evolutionary Anthropology     Display Documents



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ID: 21658.0, MPI für evolutionäre Anthropologie / Publications MPI for Evolutionary Anthropology
Evidence for population growth in humans is confounded by fine- scale population structure
Authors:Ptak, Susan E.; Przeworski, Molly
Language:English
Date of Publication (YYYY-MM-DD):2002-11
Title of Journal:Trends in Genetics
Journal Abbrev.:Trends Genet.
Volume:18
Issue / Number:11
Start Page:559
End Page:563
Review Status:not specified
Audience:Not Specified
Abstract / Description:Although many studies have reported human polymorphism data, there has been no analysis of the effect of sampling design on the patterns of variability recovered. Here, we consider which factors affect a summary of the allele-frequency spectrum. The most important variable to emerge from our analysis L is the number of ethnicities sampled: studies that sequence individuals from more ethnicities recover more rare alleles. These observations are consistent with fine-scale geographic differentiation as well as population growth. They suggest that the geographic sampling strategy should be considered carefully, especially when the aim is to infer the demographic history of humans.
Comment of the Author/Creator:Date: 2002, NOV
External Publication Status:published
Document Type:Article
Communicated by:Gisela Lausberg
Affiliations:MPI für evolutionäre Anthropologie/Department of Evolutionary Genetics
Identifiers:ISI:000178796300005 [ID No:1]
ISSN:0168-9525 [ID No:2]
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