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          Institute: MPI für evolutionäre Anthropologie     Collection: Publications MPI for Evolutionary Anthropology     Display Documents

ID: 21692.0, MPI für evolutionäre Anthropologie / Publications MPI for Evolutionary Anthropology
Intra- and interspecific variation in primate gene expression patterns
Authors:Enard, Wolfgang; Khaitovich, Philipp; Klose, Joachim; Zöllner, Sebastian; Heißig, Florian; Giavalisco, P.; Nieselt-Struwe, Kay; Muchmore, E.; Varki, Ajit; Ravid, R.; Doxiadis, G. M.; Bontrop, R. E.; Pääbo, Svante
Date of Publication (YYYY-MM-DD):2002-04-12
Title of Journal:Science
Journal Abbrev.:Science
Issue / Number:5566
Start Page:340
End Page:343
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects. The underlying genetic basis of many of these differences may be altered gene expression. We have compared the transcriptome in blood leukocytes, liver, and brain of humans, chimpanzees, orangutans, and macaques using microarrays, as well as protein expression patterns of humans and chimpanzees using two-dimensional get electrophoresis. We also studied three mouse species that are approximately as related to each other as are humans, chimpanzees, and orangutans. We identified species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain.
External Publication Status:published
Document Type:Article
Communicated by:Gisela Lausberg
Affiliations:MPI für evolutionäre Anthropologie/Department of Evolutionary Genetics
External Affiliations:Inst Humangenet Charite, D-13353 Berlin, Germany; Max Planck Inst Mol Genet, D-14195 Berlin, Germany; Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany; Univ Calif San Diego, La Jolla, CA 92093, USA; Vet Adm Med Ctr, La Jolla, CA 92093, USA; Netherlands Brain Bank, Amsterdam, Netherlands; Biomed Primate Res Ctr, Rijswijk, Netherlands
Identifiers:ISI:000175000300056 [ID No:1]
ISSN:0036-8075 [ID No:2]
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