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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents



ID: 21922.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
Commentary: Studying block in cloned N-methyl-D-aspartate (NMDA) receptors
Translation of Title:Commentary: Studying block in cloned N-methyl-D-aspartate (NMDA) receptors
Authors:Ruppersberg, J. Peter; Mosbacher, Johannes; Günther, Willy; Schoepfer, Ralf; Fakler, Bernd
Language:English
Date of Publication (YYYY-MM-DD):1993-12-03
Title of Journal:Biochem. Pharmacol.
Journal Abbrev.:Biochem. Pharmacol.
Volume:46
Issue / Number:11
Start Page:1877
End Page:1885
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The biophysics of block of NMDA receptor channels has been investigated extensively during the past 8 years. In the last few years, cloned NMDA receptor channels have become available. Here we have discussed advantages and disadvantages of studying block phenomena in cloned NMDA receptors. Some recent work on the pore block of the cloned NMDA receptor channels was critically reviewed and extended by data about the calcium block. Novel effects of kainate on cloned NMDA receptors and of NMDA on cloned AMPA receptors were reported and discussed with respect to recent work concerning possible occurrence of NMDA-AMPA hybrid channels.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie/
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
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