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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 1 - Protein Evolution (A. Lupas)     Display Documents



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ID: 222271.0, MPI für Entwicklungsbiologie / Abteilung 1 - Protein Evolution (A. Lupas)
Bartonella adhesin a mediates a proangiogenic host cell response.
Authors:Riess, T.; Andersson, S.G.; Lupas, Andrei; Schaller, M.; Schafer, A.; Kyme, P.; Martin, Jörg; Walzlein, J.H.; Ehehalt, U.; Lindroos, H.; Schirle, M.; Nordheim, A.; Autenrieth, I.B.; Kempf, V.A.
Language:English
Date of Publication (YYYY-MM-DD):2004-11-08
Title of Journal:Journal of Experimental Medicine
Journal Abbrev.:J Exp Med
Volume:200
Issue / Number:10
Start Page:1267
End Page:1278
Sequence Number of Article:15534369
Review Status:not specified
Audience:Not Specified
Abstract / Description:Bartonella henselae causes vasculoproliferative disorders in humans. We identified a nonfimbrial adhesin of B. henselae designated as Bartonella adhesin A (BadA). BadA is a 340-kD outer membrane protein encoded by the 9.3-kb badA gene. It has a modular structure and contains domains homologous to the Yersinia enterocolitica nonfimbrial adhesin (Yersinia adhesin A). Expression of BadA was restored in a BadA-deficient transposon mutant by complementation in trans. BadA mediates the binding of B. henselae to extracellular matrix proteins and to endothelial cells, possibly via beta1 integrins, but prevents phagocytosis. Expression of BadA is crucial for activation of hypoxia-inducible factor 1 in host cells by B. henselae and secretion of proangiogenic cytokines (e.g., vascular endothelial growth factor). BadA is immunodominant in B. henselae-infected patients and rodents, indicating that it is expressed during Bartonella infections. Our results suggest that BadA, the largest characterized bacterial protein thus far, is a major pathogenicity factor of B. henselae with a potential role in the induction of vasculoproliferative disorders.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 1 - Proteinevolution (Andrei Lupas)
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