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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 22331.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
A third g subunit of the g-aminobutyric acid type A receptor family
Translation of Title:A third g subunit of the g-aminobutyric acid type A receptor family
Authors:Herb, Anne; Wisden, William; Lüddens, H.; Puia, G.; Vicini, V.; Seeburg, Peter H.
Language:English
Date of Publication (YYYY-MM-DD):1992
Title of Journal:PNAS Online 1990 - Present
Journal Abbrev.:Proc. Natl. Acad. Sci. U. S. A.
Volume:89
Start Page:1433
End Page:1437
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Cloned cDNAs encoding a member of the &gamma:-aminobutyric acid type A receptor &gamma:-subunit class were isolated from rat-brain-mRNA-derived libraries. The γ3 mRNA is present in cortex, claustrum, caudate putamen, and some thalamic nuclei, particularly the medial geniculate nucleus, where it is the predominant &gamma:-subunit transcript. The γ3 gene is expressed at very low levels in cerebellum and hippocampus. In coexpression experiments with the α1 and ?2 subunits, &gamma:3 imparts benzodiazepine binding to &gamma:-aminobutyric acid type A receptors and forms γ-aminobutyric acid-gated benzodiazepine-modulated chloride channels that exhibit a larger conductance than α12 receptor channels. Furthermore, the presence of &gamma:3 in place of γ2 in α12γ receptors generates a marked decrease in the affinity of agonists while leaving the affinity of antagonists or negative modulators largely unaffected.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.pnas.org/cgi/content/abstract/89/4/1433 [Abstract]
URI:http://www.pnas.org/cgi/reprint/89/4/1433 [Fulltext PDF]
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