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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents



ID: 22455.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11
Translation of Title:Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11
Authors:Uetz, Peter; Abdelatty, Fawzy; Villarroel, Alfredo; Rappold, Gudrun; Weiss, Birgit; Koenen, Michael
Language:English
Date of Publication (YYYY-MM-DD):1994-02-21
Title of Journal:FEBS Letters
Journal Abbrev.:FEBS Lett.
Volume:339
Issue / Number:3
Start Page:302
End Page:306
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:We have isolated the murine gene encoding the 5-HT3 receptor (5-HT3R), a member of the ligand-gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5-HT3R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use ofexon 9 splice acceptor sites generated two 5-HT3R variants. The 5-HT3R gene, whose structure is closely related to neuronal and muscle AchRα genes, as demonstrated by four common splice junctions, was localised on human chromosome 11.
Free Keywords:Serotonin; Gene structure; Alternative splicing; Mouse brain; Exon alignment
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie/
Identifiers:URI:http://www.sciencedirect.com/science?_ob=ArticleUR... [Abstract]
URI:http://www.sciencedirect.com/science?_ob=MImg&_ima... [Fulltext PDF]
DOI:10.1016/0014-5793(94)80435-4
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