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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 22466.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice
Translation of Title:Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice
Authors:Brusa, Rossella; Zimmermann, Frank; Koh, D.-S.; Feldmeyer, Dirk; Gass, Peter; Seeburg, Peter H.; Sprengel, Rolf
Language:English
Date of Publication (YYYY-MM-DD):1995-12-08
Title of Journal:Science
Journal Abbrev.:Science
Volume:270
Issue / Number:5242
Start Page:1677
End Page:1680
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to calcium. The codon for this arginine is introduced at the precursor messenger RNA (pre-mRNA) stage by site-selective adenosine editing of a glutamine codon. Heterozygous mice engineered by gene targeting to harbor an editing-incompetent GluR-B allele synthesized unedited GluR-B subunits and, in principal neurons and interneurons, expressed AMPA receptors with increased calcium permeability. These mice developed seizures and died by 3 weeks of age, showing that GluR-B pre-mRNA editing is essential for brain function.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie/
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=... [Abstract]
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