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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilungsunabhängige Arbeitsgruppen     Display Documents



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ID: 225764.0, MPI für Entwicklungsbiologie / Abteilungsunabhängige Arbeitsgruppen
Neuronal migration in the murine rostral migratory stream requires serum response factor.
Authors:Alberti, S.; Krause, S.M.; Kretz, O.; Philippar, U.; Lemberger, T.; Casanova, E.; Wiebel, F.F.; Schwarz, Heinz; Frotscher, M; Schutz, G.; Nordheim, Alfred
Language:English
Date of Publication (YYYY-MM-DD):2005-04-26
Title of Journal:Proc Natl Acad Sci U S A
Volume:102
Issue / Number:17
Start Page:6148
End Page:6153
Sequence Number of Article:15837932
Review Status:not specified
Audience:Not Specified
Abstract / Description:The central nervous system is fundamentally dependent on guided cell migration, both during development and in adulthood. We report an absolute requirement of the transcription factor serum response factor (SRF) for neuronal migration in the mouse forebrain. Conditional, late-prenatal deletion of Srf causes neurons to accumulate ectopically at the subventricular zone (SVZ), a prime neurogenic region in the brain. SRF-deficient cells of the SVZ exhibit impaired tangential chain migration along the rostral migratory stream into the olfactory bulb. SVZ explants display retarded chain migration in vitro. Regarding target genes, SRF deficiency impairs expression of the beta-actin and gelsolin genes, accompanied by reduced cytoskeletal actin fiber density. At the posttranslational level, cofilin, a key regulator of actin dynamics, displays dramatically elevated inhibitory phosphorylation at Ser-3. Our studies indicate that SRF-controlled gene expression directs both the structure and dynamics of the actin microfilament, thereby determining cell-autonomous neuronal migration.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilungsunabhängige Arbeitsgruppen
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