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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents

ID: 22594.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
Target-cell-specific facilitation and depression in neocortical circuits
Translation of Title:Target-cell-specific facilitation and depression in neocortical circuits
Authors:Reyes, Alex; Lujan, R.; Rozov, Andrej; Burnashev, Nail; Somogyi, P.; Sakmann, Bert
Date of Publication (YYYY-MM-DD):1998-08
Title of Journal:Nature Neuroscience
Journal Abbrev.:Nat. Neurosci.
Issue / Number:4
Start Page:279
End Page:285
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortical layer 2/3. We induced repetitive action potentials in pyramidal cells and recorded the evoked unitary excitatory (E)PSPs in two classes of GABAergic neurons. We observed facilitation of EPSPs in bitufted GABAergic interneurons, many of which expressed somatostatin immunoreactivity. EPSPs recorded from multipolar interneurons, however, showed depression. Some of these neurons were immunopositive for parvalbumin. Unitary inhibitory (I)PSPs evoked by repetitive stimulation of a bitufted neuron also showed a less pronounced but significant difference between the two target neurons. Facilitation and depression involve presynaptic mechanisms, and because a single neuron can express both behaviors simultaneously, we infer that local differences in the molecular structure of presynaptic nerve terminals are induced by retrograde signals from different classes of target neurons. Because bitufted and multipolar neurons both formed reciprocal inhibitory connections with pyramidal cells, the results imply that the balance of activation between two recurrent inhibitory pathways in the neocortex depends on the frequency of action potentials in pyramidal cells.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie/
Identifiers:URI:http://www.nature.com/cgi-taf/DynaPage.taf?file=/n... [Abstract]
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