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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 22626.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains
Translation of Title:EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains
Authors:Brückner, Katja; Labrador, Juan Pablo; Scheiffele, Peter; Herb, Anne; Seeburg, Peter H.; Klein, Rüdiger
Language:English
Date of Publication (YYYY-MM-DD):1999-03
Title of Journal:Neuron
Journal Abbrev.:Neuron
Volume:22
Start Page:511
End Page:524
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Transmembrane ephrinB proteins have important functions during embryonic patterning as ligands for Eph receptor tyrosine kinases and presumably as signal-transducing receptor-like molecules. Consistent with reverse” signaling, ephrinB1 is localized in sphingo-lipid/cholesterol-enriched raft microdomains, platforms for the localized concentration and activation of signaling molecules. Glutamate receptor–interacting protein (GRIP) and a highly related protein, which we have termed GRIP2, are recruited into these rafts through association with the C-terminal PDZ target site of ephrinB1. Stimulation of ephrinB1 with soluble EphB2 receptor ectodomain causes the formation of large raft patches that also contain GRIP proteins. Moreover, a GRIP-associated serine/threonine kinase activity is recruited into ephrinB1–GRIP complexes. Our findings suggest that GRIP proteins provide a scaffold for the assembly of a multiprotein signaling complex downstream of ephrinB ligands.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.neuron.org/cgi/content/full/22/3/511/ [Full text]
URI:http://www.neuron.org/cgi/content/abstract/22/3/51... [Abstract]
URI:http://www.neuron.org/cgi/content/reprint/22/3/511... [Fulltext PDF]
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