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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 22631.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B
Translation of Title:Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B
Authors:Feldmeyer, Dirk; Kask, Kalev; Brusa, Rossella; Kornau, Hans Christian; Kolhekar, Rohini; Rozov, Andrej; Burnashev, Nail; Jensen, Vidar; Hvalby, Øivind; Sprengel, Rolf; Seeburg, Peter H.
Language:English
Date of Publication (YYYY-MM-DD):1999
Title of Journal:Nature Neuroscience
Journal Abbrev.:Nat. Neurosci.
Volume:2
Issue / Number:2
Start Page:57
End Page:64
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:We generated mouse mutants with targeted AMPA receptor (AMPAR) GluR–B subunit alleles, functionally expressed at different levels and deficient in Q/R–site editing. All mutant lines had increased AMPAR calcium permeabilities in pyramidal neurons, and one showed elevated macroscopic conductances of these channels. The AMPAR–mediated calcium influx induced NMDA–receptor–independent long–term potentiation (LTP) in hippocampal pyramidal cell connections. Calcium–triggered neuronal death was not observed, but mutants had mild to severe neurological dysfunctions, including epilepsy and deficits in dendritic architecture. The seizure–prone phenotype correlated with an increase in the macroscopic conductance, as independently revealed by the effect of a transgene for a Q/R–site–altered GluR–B subunit. Thus, changes in GluR–B gene expression and Q/R site editing can affect critical architectural and functional aspects of excitatory principal neurons.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie/
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.nature.com/cgi-taf/DynaPage.taf?file=/n... [Full text]
URI:http://www.nature.com/cgi-taf/DynaPage.taf?file=/n... [Abstract]
URI:http://www.nature.com/cgi-taf/DynaPage.taf?file=/n... [Fulltext PDF]
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