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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents



ID: 226364.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
Maintaining Accuracy at the Expense of Speed: Stimulus Similarity Defines Odor Discrimination Time in Mice
Translation of Title:Maintaining Accuracy at the Expense of Speed: Stimulus Similarity Defines Odor Discrimination Time in Mice
Authors:Abraham, Nixon M.; Spors, Hartwig; Carleton, Alan; Margrie, Troy W.; Kuner, Thomas; Schaefer, Andreas T.
Language:English
Date of Publication (YYYY-MM-DD):2004-12-01
Title of Journal:Neuron
Journal Abbrev.:Neuron
Volume:44
Issue / Number:5
Start Page:865
End Page:876
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Odor discrimination times and their dependence on stimulus similarity were evaluated to test temporal and spatial models of odor representation in mice. In a go/no−go operant conditioning paradigm, discrimination accuracy and time were determined for simple monomolecular odors and binary mixtures of odors. Mice discriminated simple odors with an accuracy exceeding 95%. Binary mixtures evoking highly overlapping spatiotemporal patterns of activity in the olfactory bulb were discriminated equally well. However, while discriminating simple odors in less than 200 ms, mice required 70−100 ms more time to discriminate highly similar binary mixtures. We conclude that odor discrimination in mice is fast and stimulus dependent. Thus, the underlying neuronal mechanisms act on a fast timescale, requiring only a brief epoch of odor−specific spatiotemporal representations to achieve rapid discrimination of dissimilar odors. The fine discrimination of highly similar stimuli, however, requires temporal integration of activity, suggesting a tradeoff between accuracy and speed.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie
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DOI:10.1016%2Fj.neuron.2004.11.017
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