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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 226499.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Long−term NR2B expression in the cerebellum alters granule cell development and leads top NR2A down−regulation and motor deficits
Translation of Title:Long−term NR2B expression in the cerebellum alters granule cell development and leads top NR2A down−regulation and motor deficits
Authors:Schlett, Katalin; Pieri, Isabelle; Metzger, Friedrich; Marchetti, Lara; Steigerwald, Frank; Dere, Ekrem; Kirilly, Daniel; Tarnok, Krisztian; Barabas, Brigitta; Varga, Agnes Kis; Gerspach, Jeannette; Huston, Joseph P.; Pfizenmaier, Klaus; Köhr, Georg; Eisel, Ulrich L. M.
Language:English
Date of Publication (YYYY-MM-DD):2004-11-01
Title of Journal:Mol. Cell. Neurosci.
Journal Abbrev.:Mol. Cell. Neurosci.
Volume:27
Issue / Number:3
Start Page:215
End Page:226
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:N−methyl−D−aspartate receptor (NMDAR) composition in granule cells changes characteristically during cerebellar development. To analyze the importance of NR2B replacement by NR2C and NR2A subunits until the end of the first month of age, we generated mice with lasting NR2B expression but deficiency for NR2C (NR2C−2B mice). Mutant phenotype was different from NR2C knock−out mice as loss of granule cells and morphological changes in NR2C/2B cerebellar architecture were already evident from the second postnatal week. Increased NR2B subunit levels led also to a gradual down−regulation of cerebellar NR2A levels, preceding the development of motor impairment in adult animals. Therefore, cerebellar NR2A is important for proper motor coordination and cannot be replaced by long−term expression of NR2B. Consequently, the physiological exchange of NMDA receptor subunits during cerebellar granule cell maturation is important for accurate postnatal development and function.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
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DOI:10.1016%2Fj.mcn.2004.05.008
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