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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 22777.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Prominent dendritic localization in forebrain neurons of a novel mRNA and its product, dendrin
Translation of Title:Prominent dendritic localization in forebrain neurons of a novel mRNA and its product, dendrin
Authors:Herb, Anne; Wisden, William; Catania, Maria V.; Marechal, Daniel; Dresse, Albert; Seeburg, Peter H.
Language:English
Date of Publication (YYYY-MM-DD):1997
Title of Journal:Mol. Cell. Neurosci.
Journal Abbrev.:Mol. Cell. Neurosci.
Volume:8
Start Page:367
End Page:374
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:A recently cloned rat brain cDNA derives from a novel gene, termed dendrin (DEN), expressed exclusively in forebrain structures, particularly in neocortex, olfactory bulb, hippocampus, caudate-putamen, and limbic system. In these structures, the cognate mRNA is present in neuronal cell bodies and their dendrites, whereas near exclusive dendritic localization is observed for the polypeptide product. In the hippocamus, DEN mRNA is highly expressed in the cell laminae and dendritic layers of the dentate gyrus and CA1 field, but expression is markedly reduced in the CA3 and CA4 areas. The predicted primary structure of the hydrophilic, highly basic 653-amino-acid polypeptide does not suggest a function. The restricted expression and dendritic location are compatible with a role for DEN in synaptic plasticity of central neocortical forebrain neurons.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.sciencedirect.com/science?_ob=ArticleUR... [Abstract]
URI:http://www.sciencedirect.com/science?_ob=MImg&_ima... [Fulltext PDF]
DOI:10.1006/mcne.1996.0594
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