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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 22785.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Interaction of ion channels and receptors with PDZ domain proteins
Translation of Title:Interaction of ion channels and receptors with PDZ domain proteins
Authors:Kornau, Hans Christian; Seeburg, Peter H.; Kennedy, Mary B.
Language:English
Date of Publication (YYYY-MM-DD):1997-06
Title of Journal:Current Opinion in Neurobiology
Journal Abbrev.:Curr. Opin. Neurobiol.
Volume:7
Issue / Number:3
Start Page:368
End Page:373
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:The complex anatomy of neurons demands a high degree of functional organization. Therefore, membrane receptors and ion channels are often localized to selected subcellular sites and coupled to specific signal transduction machineries. PDZ domains have come into focus as protein interaction modules that mediate the binding of a class of submembraneous proteins to membrane receptors and ion channels and thus subserve these organizational aspects. The structures of two PDZ domains have been resolved, which has led to a structural understanding of the specificity of interactions of various PDZ domains with their respective partners. The functional implications of PDZ domain interactions are now being addressed in vitro and in vivo.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.sciencedirect.com/science?_http://www.s... [Abstract]
URI:http://www.sciencedirect.com/science?_ob=MImg&_ima... [Fulltext PDF]
DOI:10.1016/S0959-4388(97)80064-5
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