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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 22884.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Connexin expression in electrically coupled postnatal rat brain neurons
Translation of Title:Connexin expression in electrically coupled postnatal rat brain neurons
Authors:Venance, Laurent; Rozov, Andrej; Blatow, Maria; Burnashev, Nail; Feldmeyer, Dirk; Monyer, Hannah
Language:English
Date of Publication (YYYY-MM-DD):2000-08-29
Title of Journal:PNAS Online 1990 - Present
Journal Abbrev.:Proc. Natl. Acad. Sci. U. S. A.
Volume:97
Issue / Number:18
Start Page:10260
End Page:10265
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Electrical coupling by gap junctions is an important form of cell-to-cell communication in early brain development. Whereas glial cells remain electrically coupled at postnatal stages, adult vertebrate neurons were thought to communicate mainly via chemical synapses. There is now accumulating evidence that in certain neuronal cell populations the capacity for electrical signaling by gap junction channels is still present in the adult. Here we identified electrically coupled pairs of neurons between postnatal days 12 and 18 in rat visual cortex, somatosensory cortex, and hippocampus. Notably, coupling was found both between pairs of inhibitory neurons and between inhibitory and excitatory neurons. Molecular analysis by single-cell reverse transcription-PCR revealed a differential expression pattern of connexins in these identified neurons.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie/
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.pnas.org/cgi/content/full/97/18/10260 [Full text]
URI:http://www.pnas.org/cgi/content/abstract/97/18/102... [Abstract]
URI:http://www.pnas.org/cgi/reprint/97/18/10260 [Fulltext PDF]
DOI:10.1073/pnas.160037097
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