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          Institute: MPI für medizinische Forschung     Collection: Abteilung Biomedizinische Optik     Display Documents



ID: 22965.0, MPI für medizinische Forschung / Abteilung Biomedizinische Optik
Dynamic optimization of odor representations by slow temporal patterning of mitral cell activity
Translation of Title:Dynamic optimization of odor representations by slow temporal patterning of mitral cell activity
Authors:Friedrich, Rainer W.; Laurent, Giles
Language:English
Date of Publication (YYYY-MM-DD):2001-02-02
Title of Journal:Science
Journal Abbrev.:Science
Volume:291
Issue / Number:5505
Start Page:889
End Page:894
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Mitral cells (MCs) in the olfactory bulb (OB) respond to odors with slow temporal firing patterns. The representation of each odor by activity patterns across the MC population thus changes continuously throughout a stimulus, in an odor-specific manner. In the zebrafish OB, we found that this distributed temporal patterning progressively reduced the similarity between ensemble representations of related odors, thereby making each odors representation more specific over time. The tuning of individual MCs was not sharpened during this process. Hence, the individual responses of MCs did not become more specific, but the odor-coding MC assemblies changed such that their overlap decreased. This optimization of ensemble representations did not occur among olfactory afferents but resulted from OB circuit dynamics. Time can therefore gradually optimize stimulus representations in a sensory network.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Biomedizinische Optik/
Identifiers:URI:http://www.sciencemag.org/cgi/content/full/291/550... [Full text]
URI:http://www.sciencemag.org/cgi/content/abstract/291... [Abstract]
URI:http://www.sciencemag.org/cgi/reprint/291/5505/889 [Fulltext PDF]
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