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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2004     Display Documents



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ID: 229800.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2004
Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis.
Authors:Knoch, Klaus-Peter; Bergert, Hendrik; Borgonovo, Barbara; Saeger, Hans-Detlev; Altkruger, Anke; Verkade, Paul; Solimena, Michele
Date of Publication (YYYY-MM-DD):2004
Title of Journal:Nature Cell Biology
Volume:6
Issue / Number:3
Start Page:207
End Page:214
Copyright:not available
Review Status:not specified
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Pancreatic beta-cells store insulin in secretory granules that undergo exocytosis upon glucose stimulation. Sustained stimulation depletes beta-cells of their granule pool, which must be quickly restored. However, the factors promoting rapid granule biogenesis are unknown. Here we show that beta-cell stimulation induces the nucleocytoplasmic translocation of polypyrimidine tract-binding protein (PTB). Activated cytosolic PTB binds and stabilizes mRNAs encoding proteins of secretory granules, thus increasing their translation, whereas knockdown of PTB expression by RNA interference (RNAi) results in the depletion of secretory granules. These findings may provide insight for the understanding and treatment of diabetes, in which insulin secretion is typically impaired.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:498
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