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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents

ID: 230803.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Hox cluster disintegration with persistent anteroposterior order of expression in Oikopleura dioica
Authors:Seo, Hee-Chan; Edvardsen, Rolf Brudvik; Maeland, Anne Dorthea; Bjordal, Marianne; Jensen, Marit Flo; Hansen, Anette; Flaat, Mette; Weissenbach, Jean; Lehrach, Hans; Wincker, Patrick; Reinhardt, Richard; Chourrout, Daniel
Date of Publication (YYYY-MM-DD):2004-09-02
Title of Journal:Nature
Issue / Number:7004
Start Page:67
End Page:71
Copyright:© 2004 Nature Publishing Group
Review Status:not specified
Audience:Experts Only
Abstract / Description:Tunicate embryos and larvae have small cell numbers and simple anatomical features in comparison with other chordates, including vertebrates. Although they branch near the base of chordate phylogenetic trees, their degree of divergence from the common chordate ancestor remains difficult to evaluate. Here we show that the tunicate Oikopleura dioica has a complement of nine Hox genes in which all central genes are lacking but a full vertebrate-like set of posterior genes is present. In contrast to all bilaterians studied so far, Hox genes are not clustered in the Oikopleura genome. Their expression occurs mostly in the tail, with some tissue preference, and a strong partition of expression domains in the nerve cord, in the notochord and in the muscle. In each tissue of the tail, the anteroposterior order of Hox gene expression evokes spatial collinearity, with several alterations. We propose a relationship between the Hox cluster breakdown, the separation of Hox expression domains, and a transition to a determinative mode of development.
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:Sars Centre for Marine Molecular Biology, Bergen High Technology Centre, Thormøhlensgaten 55, 5008 Bergen, Norway;
Genoscope-Centre National de Sequencage and CNRS UMR-8030, 91000 Evry, France
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