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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



ID: 230841.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Retroelement Dynamics and a Novel Type of Chordate Retrovirus-like Element in the Miniature Genome of the Tunicate Oikopleura dioica
Authors:Volff, Jean-Nicolas; Lehrach, Hans; Reinhardt, Richard; Chourrout, Daniel
Language:English
Date of Publication (YYYY-MM-DD):2004-11
Title of Journal:Molecular Biology and Evolution
Journal Abbrev.:Mol Biol Evol
Volume:21
Issue / Number:11
Start Page:2022
End Page:2033
Copyright:© Society for Molecular Biology and Evolution 2004
Review Status:not specified
Audience:Experts Only
Abstract / Description:Retrotransposable elements have played an important role in shaping eukaryotic DNA, and their activity and turnover rate directly influence the size of genomes. With approximately 15,000 genes within 65–75 megabases, the marine tunicate Oikopleura dioica, a nonvertebrate chordate, has the smallest and most compact genome ever found in animals. Consistent with a massive elimination of retroelements, only one apparently novel clade of non–long terminal repeat (non-LTR) retrotransposons was detected within 41 megabases of nonredundant genomic sequences. In contrast, at least six clades of non-LTR elements were identified in the less compact genome of the tunicate Ciona intestinalis. Unexpectedly, Ty3/gypsy-related Tor LTR retrotransposons presented an astonishing level of diversity in O. dioica. They were generally poorly or apparently not corrupted, indicating recent activity. Both Tor3 and Tor4b families bore an envelope-like open reading frame, suggesting possible horizontal acquisition through infection. The Tor4b envelope-like gene might have been obtained from a paramyxovirus (RNA virus). Tor3 and Tor4b are phylogenetically clearly distinct from vertebrate retroviruses (Retroviridae) and are more reminiscent of certain insect and plant sequences. Tor elements potentially represent a so far unknown, ancient type of infectious retroelement in chordates. Their distribution and transmission dynamics in tunicates and other chordates deserve further study.
Free Keywords:Oikopleura; retroelement; retrovirus; compact genome; reverse transcriptase; envelope
Comment of the Author/Creator:Published online: 2004-07-14
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:Biofuture Research Group, Physiologische Chemie I, Biozentrum, University of Würzburg, am Hubland, Würzburg, Germany;
Sars Centre for Marine Molecular Biology, Bergen High Technology Centre, Bergen, Norway
Identifiers:ISSN:0737-4038
DOI:10.1093/molbev/msh207
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